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We also know that many patients with psoriasis are receiving either short-term steroid tapers or judicious long-term, low-dose prednisone for psoriatic arthritis without apparent ill effects. The purpose of this study was to determine whether the long-term use of a steroid for psoriasis could produce long-term structural changes in the connective tissues of the spine, particularly in the spinal cord, during the early years after steroids discontinuing. The principal findings were: 1) there was evidence of structural changes in the bones, and 2) we found a significant reduction in the vertebral artery (VAS) diameter. These data suggest that long-term steroid administration in psoriatic arthritis patients could enhance the risk of death and disability resulting from the disease rather than decreasing it. For more information about Steroid Use in Health Care, read the article by: Y. Maiti Aghajanian, et al. Spinal Cord Dysfunction in Psoriatic Arthritis. Journal Of Investigative Dermatology, vol. 115(1), pp. 5 - 7. A.J. Pate, et al. Association Between Steroid Administration and Cardiac Dysfunction in Psoriasis Patients. Journal of the American Academy of Dermatology, vol. 68(4), pp. 661 - 665. K.L. Al-Saad, et al. Chronic Psoriasis (Treatment of Acute and Chronic Progression of Acute Psoriasis in Patients who Can Still Feel Pain): A Comparison of Two Controlled Trials. Journal of the American Academy of Dermatology, vol. 62(2), pp. 137 - 139. T.E. Raffensbach, et al. Effects on the Spine of Acute Cerebrovascular Disease, and the Relationship to Steroid Hormone Administration. Journal of the American Academy of Dermatology, vol. 60(4), pp. 523 - 530. K.K. Shikany, et al. Dose-dependent Relationship of Steroid Hormone Administration to Cerebral Volume and Cardiac Volume in Patients with Chronic Venous Insufficiency. Clinical Journal of Pain, vol. 5(2), pp. 95 - 101. D.H. Vickers, et al. Comparison of Serum Plasma Levels and CSF Levels of Steroids and Anti-TNF Agents in Patients with Chronic Venous Insufficiency. Journal of the American Academy of Dermatology, vol. 60(2), pp. 549 - 559. S.M. Yassin, et al. Low-dose Related Article: